Research
Biological systems, such as those controlling circadian clocks are highly complex and cannot be fully understood without computational methods. Mathematical modeling, simulation, and analysis are important tools in biological discovery. In our lab, we focus on model-building and analysis for oscillators in general and circadian clocks, specifically.
Selected Publications
- SR Taylor, AB Webb, LR Petzold, FJ Doyle III, Velocity Response Curves Support the Role of Continuous Entrainment in Circadian Clocks, submitted
- SR Taylor, FJ Doyle III, LR Petzold, Oscillator Model Reduction Preserving the Phase Response: Application to the Circadian Clock, Biophys. J., 95:1658-1673, 2008
- N Bagheri*, SR Taylor*, K Meeker, LR Petzold, FJ Doyle III. Synchrony and Entrainment Properties of Robust Circadian Oscillators, J. R. Soc. Interface, 5:S17-28, 2008
(*Equal contribution)
- SR Taylor, R Gunawan, LR Petzold, and FJ Doyle III. Sensitivity Measures for Oscillating Systems: Application to Mammalian Circadian Gene Network, IEEE Trans. Automat. Contr., 153:177-188, 2008
- MN Zeilinger*, EM Farre*, SR Taylor, SA Kay, and FJ Doyle III. A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9. Mol. Syst. Biol. 2:58, 2006 (* Equal contribution)
Students
- Olena Marchenko - Olena is augmenting a mathematical model of the circadian clock in the plant Arabidopsis thalian to include a new regulatory loop. Addition of the new loop should improve the predictive capability of the current models.
- Katherine Smith - Katherine has shown that realistic phase-only models of the mouse circadian clock can entrain to natural, highly variable light/dark cycles.